Invitrogen™ Ku70/Ku80 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599488

Catalog No. PIPA599488

Description

Antibody detects endogenous levels of total Ku70/80.

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].

Specifications

• Antigen: Ku70/Ku80
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: XRCC5
• Gene Alias: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 5'-dRP/AP lyase Ku70; 70 kDa subunit of Ku antigen; 70kDa; 86 kDa subunit of Ku antigen; AI314015; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II 80 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC75; CTC85; CTCBF; DNA repair protein XRCC5; DNA repair protein XRCC6; G22P1; G22P2; KARP1; KARP-1; Ku autoantigen p70 subunit; ku autoantigen protein p70 homolog; Ku autoantigen protein p86 homolog; Ku autoantigen, 70kDa; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku p70; Ku p80; KU70; Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa); KU80; Ku86; Ku86 autoantigen related protein 1; KUB2; Kup70; Kup80; lupus Ku autoantigen protein p70; Lupus Ku autoantigen protein p86; ML8; NFIV; Nuclear factor IV; thyroid autoantigen; thyroid autoantigen 70 kDa; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; XELAEV_18023498mg; XELAEV_18044412mg; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa); X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair complementing defective repair in Chinese hamster cells 6 L homeolog; X-ray repair cross complementation (double-strand-break rejoining; X-ray repair cross complementation (double-strand-break rejoining; Ku autoantigen, 80kD); X-ray repair cross complementing 5; X-ray repair cross complementing 6; X-ray repair cross-complementing protein 5; X-ray repair cross-complementing protein 6; xrcc5; xrcc5.L; xrcc5-a; Xrcc6; xrcc6.L
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14375, 22596, 25019, 2547, 363247, 7520
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P12956, P13010, P23475, P27641
• Gene Symbols: XRCC5, XRCC6
• Immunogen: A synthesized peptide derived from human XRCC6(Accession P12956), corresponding to amino acid residues I213-L263.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov