Ku70/XRCC6 Mouse, Clone: KU729, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP234247F	Novus Biologicals NBP2342470.02MG	0.02 mg
NBP234247A	Novus Biologicals NBP2342470.1MG	0.1 mg
NBP234247B	Novus Biologicals NBP2342470.2MG	0.2 mg

Description

Ku70/XRCC6 Monoclonal specifically detects Ku70/XRCC6 in Human, Primate, Chicken (Negative), Mouse (Negative), Rat (Negative) samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Flow (Intracellular).

Specifications

• Antigen: Ku70/XRCC6
• Dilution: Immunocytochemistry/Immunofluorescence 0.5-1.0ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, Immunohistochemistry-Paraffin 0.5-1ug/ml, Immunohistochemistry-Frozen 0.5-1ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human, Primate, Chicken (Negative), Mouse (Negative), Rat (Negative)
• Gene Accession No.: P12956
• Gene ID (Entrez): 2547
• Immunogen: Nuclear extract of human HL-60 cells
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.
• Molecular Weight of Antigen: 75 kDa

• Clone: KU729
• Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Breast Cancer, Cancer, DNA Double Strand Break Repair, DNA Repair, Non homologous end joining
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, D22S731, EC 3.6.4.-, EC 4.2.99.-, G22P1Ku70, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, KU70, ML8,70 kDa subunit, Thyroid-lupus autoantigen, thyroid-lupus autoantigen p70, TLAAD22S671, X-ray repair complementing defective repair in Chinese hamster cells 6DNA repair protein XRCC6, X-ray repair cross-complementing protein 6
• Gene Symbols: XRCC6
• Isotype: IgG1 κ
• Purification Method: Protein A purified
• Test Specificity: Recognizes a dimer of two proteins of 70kDa and ∼80kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.