Invitrogen™ KV1.8 (KCNA10) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA541032

Catalog No. PIPA541032

Description

Peptide sequence: PANVPIDIFA DEISFYELGS EAMDQFREDE GFIKDPETLL PTNDIHRQFW Sequence homology: Cow: 100%; Dog: 92%; Guinea Pig: 92%; Human: 100%; Mouse: 100%; Rat: 100%.

KCNA10 is a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.

Specifications

• Antigen: KV1.8 (KCNA10)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNA10
• Gene Alias: cyclic GMP gated potassium channel; Gm1962; Kcn1; KCNA10; Kcna8; Kv1.8; potassium channel, voltage gated shaker related subfamily A, member 10; potassium voltage gated channel, shaker related subfamily, member 8; potassium voltage-gated channel subfamily A member 10; potassium voltage-gated channel, shaker-related subfamily, member 10; potassium voltage-gated channel, shaker-related subfamily, member 8; voltage-gated potassium channel subunit Kv1.8
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3744
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q16322
• Gene Symbols: KCNA10
• Immunogen: Synthetic peptide directed towards the middle region of human KCNA10.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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