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Invitrogen™ KV1.8 (KCNA10) Polyclonal Antibody
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Catalog No. PIPA541031
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100 μL
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PIPA541031 100 μL
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Catalog No. PIPA541031 Supplier Invitrogen™ Supplier No. PA541031
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Description

Rabbit Polyclonal Antibody

Peptide sequence: DVCGWKEMEV ALVNFDNSDE IQEEPGYATD FDSTSPKGRP GGSSFSNGKI Sequence homology: Cow: 92%; Dog: 79%; Guinea Pig: 93%; Horse: 85%; Human: 100%; Mouse: 86%; Rat: 93%.

KCNA10 is a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen KV1.8 (KCNA10)
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene KCNA10
Gene Accession No. Q16322
Gene Alias cyclic GMP gated potassium channel; Gm1962; Kcn1; KCNA10; Kcna8; Kv1.8; potassium channel, voltage gated shaker related subfamily A, member 10; potassium voltage gated channel, shaker related subfamily, member 8; potassium voltage-gated channel subfamily A member 10; potassium voltage-gated channel, shaker-related subfamily, member 10; potassium voltage-gated channel, shaker-related subfamily, member 8; voltage-gated potassium channel subunit Kv1.8
Gene Symbols KCNA10
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human KCNA10 (aa 2-51).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3744
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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