KV3.2 (KCNC2) Mouse anti-Human, Mouse, Rat, Clone: S410-17, Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA527683

Catalog No. PIMA527683

Description

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels. The subunits vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits, which include the KV1, KV2, KV3, KV4 and KV9 proteins, as well as accessory subunits that modify the gating properties of the coexpressed KV subunits. KV3.2 is a multipass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. The tail of KV3.2 may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.

Specifications

• Antigen: KV3.2 (KCNC2)
• Classification: Monoclonal
• Concentration: 1 mg/ml
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
• Gene Accession No.: P22462, Q14B80, Q96PR1
• Gene Symbols: Kcnc2
• Immunogen: Fusion protein amino acids 474-613 (Cytoplasmic C-terminus) of rat Kv3.2a
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
• Clone: S410-17
• Conjugate: Unconjugated
• Gene: KCNC2
• Gene Alias: Potassium voltage-gated channel subfamily C member 2, Kcnc2, KSHIIIA
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 246153, 268345, 3747
• Content And Storage: -20°C
• Form: Liquid