Invitrogen™ KV3.2 (KCNC2) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536072

Catalog No. PIPA536072

Description

This antibody detects endogenous protein at a molecular weight of 70 kDa. Purity is >95% by SDS-PAGE.

Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. The KV gene family encodes more than 30 proteins that comprise the subunits of the K+ channels. The subunits vary in their gating and permeation properties, subcellular distribution and expression patterns. Functional KV channels assemble as tetramers consisting of pore-forming alpha subunits, which include the KV1, KV2, KV3, KV4 and KV9 proteins, as well as accessory subunits that modify the gating properties of the coexpressed KV subunits. KV3.2 is a multipass membrane protein that regulates the voltage-dependent K+ permeability of excitable membranes. The tail of KV3.2 may be influential in the targeting of the channel to specific subcellular compartments and/or the regulation of channel activity.

Specifications

• Antigen: KV3.2 (KCNC2)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KCNC2
• Gene Alias: AW047325; B230117I07; KCNC2; KShIIIA; Kv3.2; Potassium channel voltage-gated Shaw-related subfamily C member 2; potassium channel, voltage gated Shaw related subfamily C, member 2; potassium channel, voltage gated Shaw-related subfamily C, member 2; potassium voltage gated channel, Shaw-related subfamily, member 2; potassium voltage-gated channel subfamily C member 2; potassium voltage-gated channel, Shaw-related subfamily, member 2; shaw-like potassium channel; Voltage-gated potassium channel Kv3.2; voltage-gated potassium channel subunit Kv3.2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 246153, 268345, 3747
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: P22462, Q14B80, Q96PR1
• Gene Symbols: KCNC2
• Immunogen: Synthetic peptide corresponding to amino acids 590-638 of Human KV3.2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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