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  5. Tocris Bioscience™ KYP 2047

Tocris Bioscience™ KYP 2047
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Catalog No. 62725
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25 mg
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Catalog No. Quantity
62-725 5 mg
62-722-5 25 mg
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Catalog No. 62-725 Supplier Tocris Bioscience™ Supplier No. 6272/5
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Description

High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo, treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.

Specifications

Chemical Name or Material (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
CAS 796874-99-2
Quantity 5 mg
Molecular Formula C20H25N3O2
Formula Weight 339.44
Purity 98%
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