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Tocris Bioscience™ KYT 0353
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Catalog No. 50265
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50-265 5 mg
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Catalog No. 50-265 Supplier Tocris Bioscience™ Supplier No. 5026/5
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Description

Potent and selective inhibitor of L-type amino acid transporter 1 (LAT1)

KYT 0353 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1) (IC50 = 60 nM for 14C-leucine uptake in H-29 cells). Also suppreses 14C-leucine uptake in renal proximal tubule cells expressing LAT1 (IC50 = 140 nM). Displays ∽500-fold selectivity for LAT1 over LAT2. Reduces cell viability and induces apoptosis in YD-38 oral cancer cells. Arrests growth in several tumor cell lines. Exhibits growth inhibitory effects on HT-29 cells in vivo.

Specifications

Chemical Name or Material O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride
CAS 1597402-27-1
Synonym JPH 203
Quantity 5 mg
Molecular Formula C23H19Cl2N3O4.2HCl
Formula Weight 545.24
Product Type Inhibitor
Purity 96%
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