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Tocris Bioscience™ L-168,049
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Catalog No. 231150
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Catalog No. Quantity
23-115-0 50 mg
23-111-0 10 mg
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Catalog No. 23-115-0 Supplier Tocris Bioscience™ Supplier No. 2311/50
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Description

Potent, orally active human glucagon receptor antagonist

Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo.

Chemical Identifiers

CAS 191034-25-0
Molecular Formula C24H20BrClN2O

Specifications

Quantity 50 mg
Formula Weight 467.79
Purity >99%
Molecular Weight (g/mol) 467.791
Chemical Name or Material L-168, 049

Safety and Handling

Recommended Storage Store at Room Temperature
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