Tocris Bioscience™ L-655,708

Description

Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors

Potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

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Specifications

Chemical Identifiers

• CAS: 130477-52-0
• Molecular Formula: C18H19N3O4

• Quantity: 10 mg
• Formula Weight: 341.37
• Purity: >99%
• Molecular Weight (g/mol): 341.367
• Chemical Name or Material: L-655, 708

Safety and Handling

Recommended Storage

Desiccate at +4°C