Invitrogen™ L-Plastin Recombinant Rabbit Monoclonal Antibody (JE48-95)

Catalog No.	Quantity
PIMA534865	100 μL

Catalog No. PIMA534865

Supplier: Invitrogen™ MA534865

Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Human tonsil tissue, human lung cancer tissue, human colon tissue, human appendix tissue, human spleen tissue.

L-plastin is a leukocyte specific actin bundling protein from fimbrin family of proteins. It has two actin-binding domains and two EF hand type calcium-binding domains. It gets phosphorylated on the serine residue in its headpiece region in response to a variety of inflammatory stimuli. It is hypothesized that L-plastin may play a role in regulating integrin mediated adhesion in leukocytes. L-plastin is expressed in majority of human cancer cell lines derived from solid tumors. Its expression is positively upregulated by testosterones in androgen receptor positive prostrate and breast cancer cells through three androgen receptor binding elements located in the upstream region of the gene.

Specifications

• Antigen: L-Plastin
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: JE48-95
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene: LCP1
• Gene Accession No.: P13796
• Gene Alias: 65 kDa macrophage protein; AW536232; bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); cb245; CP64; D14Ertd310e; DKFZp781A23186; epididymis secretory protein Li 37; fj24b12; FLJ25423; FLJ26114; FLJ39956; HEL-S-37; LC64P; LCP1; LCP-1; leucocyte-specific plastin 1; L-fimbrin; LPL; L-plastin; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); lymphocyte cytosolic plastin 1; lymphocyte cytosolic protein 1; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin 2, L; plastin-2; Pls2; pp65; wu:fj24b12
• Gene Symbols: LCP1
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human Plastin L aa 461-627.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3936
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov