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Invitrogen™ L3MBTL1 Chimeric Recombinant Rabbit Monoclonal Antibody (RAB-C213)
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Catalog No. PIMA548334
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200 μg
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PIMA548334 200 μg
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Catalog No. PIMA548334 Supplier Invitrogen™ Supplier No. MA548334
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody recognizes L3MBTL1 (Lethal(3)malignant brain tumor-like protein 1). It binds to a folded domain, amino acids 200-530. L3MBTL1 is a Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications.

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
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Specifications

Antigen L3MBTL1 Chimeric
Applications ChIP Assay, ELISA, Flow Cytometry, Immunoprecipitation, Immunocytochemistry
Classification Recombinant Monoclonal
Clone RAB-C213
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene L3MBTL1
Gene Accession No. Q9Y468
Gene Alias C630004G01; dJ138B7.3; H-l(3)mbt; H-l(3)mbt protein; Kiaa0681; L(3)mbt protein homolog; l(3)mbt-like (Drosophila); l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3mbt; L3MBTL; L3MBTL histone methyl-lysine binding protein 1; L3MBTL1; L3MBTL1, histone methyl-lysine binding protein; lethal (3) malignant brain tumor l(3); lethal(3)malignant brain tumor-like protein 1; lethal(3)malignant brain tumor-like protein 1; serine/threonine-protein kinase Sgk2; LOC100070683; mKIAA0681; RGD1307316; RP1-138B7.1; ZC2HC3
Gene Symbols L3MBTL1
Host Species Rabbit
Immunogen This antibody was obtained by recombinant antibody (rAb) phage display recognizing L3MBTL1 protein under non-denaturing conditions.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26013
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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