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Invitrogen™ L3MBTL1 Polyclonal Antibody
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Catalog No. PIPA530499
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100 μL
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PIPA530499 100 μL
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Catalog No. PIPA530499 Supplier Invitrogen™ Supplier No. PA530499
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa nucleus, human L3MBTL-transfected 293T. Predicted reactivity: Mouse (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen L3MBTL1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene L3MBTL1
Gene Accession No. Q9Y468
Gene Alias C630004G01; dJ138B7.3; H-l(3)mbt; H-l(3)mbt protein; Kiaa0681; L(3)mbt protein homolog; l(3)mbt-like (Drosophila); l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3mbt; L3MBTL; L3MBTL histone methyl-lysine binding protein 1; L3MBTL1; L3MBTL1, histone methyl-lysine binding protein; lethal (3) malignant brain tumor l(3); lethal(3)malignant brain tumor-like protein 1; lethal(3)malignant brain tumor-like protein 1; serine/threonine-protein kinase Sgk2; LOC100070683; mKIAA0681; RGD1307316; RP1-138B7.1; ZC2HC3
Gene Symbols L3MBTL1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human L3MBTL1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26013
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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