Invitrogen™ L3MBTL1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521518

Catalog No. PIPA521518

Description

Recommended positive controls: HeLaS3, human L3MBTL-transfected 293T. Predicted reactivity: Mouse (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

L3MBTL1 is the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. L3MBTL1 is localized to condensed chromosomes in mitotic cells and overexpression of this protein in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. L3MBTL1 represents a polycomb group gene the encoded protein functions to regulate gene activity, likely via chromatin modification. Polycomb group protein specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a reader of a network of post-translational modifications. Alternatively spliced transcript variants encoding different isoforms of the L3MBTL1 gene have been identified.

Specifications

• Antigen: L3MBTL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: L3MBTL1
• Gene Alias: C630004G01; dJ138B7.3; H-l(3)mbt; H-l(3)mbt protein; Kiaa0681; L(3)mbt protein homolog; l(3)mbt-like (Drosophila); l(3)mbt-like 1; l(3)mbt-like 1 (Drosophila); L3mbt; L3MBTL; L3MBTL histone methyl-lysine binding protein 1; L3MBTL1; L3MBTL1, histone methyl-lysine binding protein; lethal (3) malignant brain tumor l(3); lethal(3)malignant brain tumor-like protein 1; lethal(3)malignant brain tumor-like protein 1; serine/threonine-protein kinase Sgk2; LOC100070683; mKIAA0681; RGD1307316; RP1-138B7.1; ZC2HC3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26013
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y468
• Gene Symbols: L3MBTL1
• Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 365 and 723 of L3MBTL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, C. elegans
• Product Type: Antibody
• Isotype: IgG