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Invitrogen™ L3MBTL2 Monoclonal Antibody (4F4)
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Catalog No. PIMA522704
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100 μg
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Catalog No. Quantity
PIMA522704 100 μg
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Catalog No. PIMA522704 Supplier Invitrogen™ Supplier No. MA522704
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Description

Mouse Monoclonal Antibody

Peptide Sequence: RQGSKKPLLE DDPQGARKIS SEPVPGEIIA VRVKEEHLDV ASPDKASSPE LPVSVENIKQ ETDD.

The L3MBTL2 gene encodes a protein that belongs to the MBT (malignant brain tumor) family, which is characterized by the presence of MBT domains. These proteins are known for their role in chromatin organization and transcriptional repression. L3MBTL2 specifically acts as a transcriptional repressor, capable of compacting chromatin independent of histone modifications, thereby facilitating gene silencing. Its repressive activity is associated with the suppression of specific target genes, such as CGA in pancreatic cells, indicating its potential role in regulating cellular differentiation and proliferation. The MBT domains in L3MBTL2 are methyl-lysine readers that further contribute to its role in modulating chromatin state, impacting stem cell maintenance and developmental processes. Understanding L3MBTL2's functions and interactions is crucial due to its involvement in maintaining genomic integrity and its implications in cancer biology, particularly in chromatin-mediated gene regulation mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen L3MBTL2
Applications ELISA, Western Blot
Classification Monoclonal
Clone 4F4
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene L3MBTL2
Gene Accession No. Q969R5
Gene Alias 4732493N06Rik; H-l(3)mbt-l; H-l(3)mbt-like protein 2; l(3)mbt-like 2; l(3)mbt-like 2 (Drosophila); l(3)mbt-like 2 protein; L(3)mbt-like protein 2; L3MBT; L3MBTL histone methyl-lysine binding protein 2; L3MBTL2; L3MBTL2 polycomb repressive complex 1 subunit; L3MBTL2, polycomb repressive complex 1 subunit; lethal(3)malignant brain tumor-like 2 protein; lethal(3)malignant brain tumor-like protein 2; lmbt-like 2 (Drosophila) isoform 1; lmbt-like 2 (Drosophila) isoform 2; M4mbt
Gene Symbols L3MBTL2
Host Species Mouse
Immunogen L3MBTL2 (NP_113676, 642 a.a. ~ 705 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83746
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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