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Invitrogen™ L3MBTL2 Polyclonal Antibody
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Catalog No. PIPA587816
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100 μL
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PIPA587816 100 μL
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Catalog No. PIPA587816 Supplier Invitrogen™ Supplier No. PA587816
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PATFCQKNDI ELTPPKGYEA QTFNWENYLE KTKSKAAPSR LFNMDCPNHG FKVGMKLEAV DLMEPRLICV ATVKRVVHRL LSIHFDGWDS EYDQWVDCES PDIYPVGWCE LTGYQLQPPV AAEPATPLKA KEATKKKKKQ FGKKRKRIPP TKTRPLRQGS KKPLLEDDPQ GARKISSEPV PGEIIAVRVK EEHLDVASPD KASSPELPVS VENIKQETDD; Positive Samples: HeLa, HL-60, HT-29; Cellular Location: Nucleus.

The L3MBTL2 gene encodes a protein that belongs to the MBT (malignant brain tumor) family, which is characterized by the presence of MBT domains. These proteins are known for their role in chromatin organization and transcriptional repression. L3MBTL2 specifically acts as a transcriptional repressor, capable of compacting chromatin independent of histone modifications, thereby facilitating gene silencing. Its repressive activity is associated with the suppression of specific target genes, such as CGA in pancreatic cells, indicating its potential role in regulating cellular differentiation and proliferation. The MBT domains in L3MBTL2 are methyl-lysine readers that further contribute to its role in modulating chromatin state, impacting stem cell maintenance and developmental processes. Understanding L3MBTL2's functions and interactions is crucial due to its involvement in maintaining genomic integrity and its implications in cancer biology, particularly in chromatin-mediated gene regulation mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen L3MBTL2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 4.89 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene L3MBTL2
Gene Accession No. Q969R5
Gene Alias 4732493N06Rik; H-l(3)mbt-l; H-l(3)mbt-like protein 2; l(3)mbt-like 2; l(3)mbt-like 2 (Drosophila); l(3)mbt-like 2 protein; L(3)mbt-like protein 2; L3MBT; L3MBTL histone methyl-lysine binding protein 2; L3MBTL2; L3MBTL2 polycomb repressive complex 1 subunit; L3MBTL2, polycomb repressive complex 1 subunit; lethal(3)malignant brain tumor-like 2 protein; lethal(3)malignant brain tumor-like protein 2; lmbt-like 2 (Drosophila) isoform 1; lmbt-like 2 (Drosophila) isoform 2; M4mbt
Gene Symbols L3MBTL2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 486-705 of human L3MBTL2 (NP_1136762).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83746
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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