Epredia™ Lab Vision™ c-Abl Ab-1 Mouse Monoclonal Antibody, biotin labeled with BSA and azide

Obtain accurate, reproducible results in immunohistochemistry, western blotting, immunofluorescence, and immunoprecipitation procedures.

Supplier:  Epredia™ MS938B1

Catalog No. MS938B1

Description

The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Host Species: Mouse

Clone: 8E9

Isotype: IgG1/γ

Species Reactivity: Human and Mouse. Others not tested.

Epitope: SH2 domain

Immunogen: Recombinant Abl protein

Molecular Weight: 120kDa

Positive Control: HeLa cells or placenta

Cellular Localization: Cytoplasmic and nuclear

Ab-1 reacts with c-Abl p120 and chimeric Bcr/Abl proteins.

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunofluorescence
• Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: c-Abl Ab-1
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Research Discipline: Signal Transduction
• Target Species: Human, Mouse
• Isotype: IgG1

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: 8E9
• Conjugate: Biotin
• Immunogen: Recombinant Abl protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated