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  6. Epredia™ Lab Vision™ Cyclin B1 Ab-2 Rabbit Polyclonal Antibody with BSA and azide

Epredia™ Lab Vision™ Cyclin B1 Ab-2 Rabbit Polyclonal Antibody with BSA and azide

Catalog No. RB008P Shop All Epredia Products
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Quantity:
100 μL
500 μL
1 mL
Formulation:
Purified w/o BSA and Azide
Purified with BSA and Azide
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Catalog No. Quantity Formulation
RB008P 1 mL Purified with BSA and Azide
RB008P0 100 μL Purified with BSA and Azide
RB008P1ABX 500 μL Purified w/o BSA and Azide
RB008PABX 1 mL Purified w/o BSA and Azide
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Catalog No. RB008P Supplier Epredia™ Supplier No. RB008P

Description

Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

In mammals, cyclin B associates with inactive p34cdc2 which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse and Rat. Others not known.

Epitope: C-terminal

Immunogen: A synthetic peptide derived from the C-terminus of human cyclin B1

Molecular Weight: 62 kDa

Positive Control: Jurkat, Ls174T, HeLa cells; Breast CA

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Native and denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen Cyclin B1 Ab-2
Applications Immunoprecipitation
Classification Polyclonal
Clone Polyclonal
Concentration 1mg/mL
Conjugate Unconjugated
Formulation Purified with BSA and Azide
Host Species Rabbit
Immunogen A synthetic peptide derived from the C-terminus of human cyclin B1
Quantity 1 mL
Regulatory Status RUO
Research Discipline Cell Cycle
Primary or Secondary Primary
Target Species Human, Mouse
Form Concentrated
Isotype IgG
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