DOG1 Mouse Monoclonal Antibody, Epredia™

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Mouse Monoclonal Antibody.

Supplier:  Epredia MS1933R7

Catalog No. MS1933R7

Description

DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody¹. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase². In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Mouse

Clone: 1.1

Isotype: Unknown

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: Dog1
• Clone: 1.1
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide of human Dog1
• Primary or Secondary: Primary
• Form: Ready-to-Use

• Applications: Immunohistochemistry
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 7 mL
• Target Species: Human