Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio.

Supplier:  Epredia™ RM9132R1

Catalog No. RM9132R1

Description

DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Rabbit

Clone: SP31

Isotype: IgG

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membranous

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Specifications

• Antigen: DOG1
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Rabbit
• Quantity: 1 mL
• Research Discipline: Cancer and Tumor Biology
• Target Species: Human
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Clone: SP31
• Formulation: Ready-to-use for IHC (UVLP)
• Immunogen: Synthetic peptide of human Dog1
• Regulatory Status: IVD
• Primary or Secondary: Primary
• Form: Prediluted