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  6. Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody

Epredia™ Lab Vision™ DOG1 Rabbit Monoclonal Antibody

Catalog No. RM9132RQ Shop All Epredia Products
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Quantity:
100 μL
1 mL
7 mL
12 mL
Form:
Concentrated
Prediluted
Ready-to-Use
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Catalog No. Quantity Form
RM9132RQ 12 mL Ready-to-Use
RM9132S0 100 μL Concentrated
RM9132R1 1 mL Prediluted
RM9132R7 7 mL Prediluted
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Catalog No. RM9132RQ Supplier Epredia™ Supplier No. RM9132RQ

Description

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ Dog1, Rabbit Monoclonal Antibody, part of a comprehensive antibody portfolio.

DOG1 is a cell surface protein of unknown function selectively expressed in GIST. Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosin kinase. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Rabbit

Clone: SP31

Isotype: IgG

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membranous

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Specifications

Antigen DOG1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SP31
Conjugate Unconjugated
Host Species Rabbit
Immunogen Synthetic peptide of human Dog1
Quantity 12 mL
Regulatory Status IVD
Research Discipline Cancer and Tumor Biology
Primary or Secondary Primary
Form Ready-to-Use
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