Epidermal Growth Factor Receptor/EGFR Ab-10 Mouse Monoclonal Antibody, Epredia™

Ensure accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments.

Supplier:  Epredia MS378R1

Catalog No. MS378R1

Description

EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Host Species: Mouse

Clone: 111.6

Isotype: IgG1

Species Reactivity: Human. Not mouse and rat.

Epitope: Extracellular domain

Immunogen: Extracellular domain of human recombinant EGFR protein

Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)

Positive Control: A431 cells; Skin, Placenta or Squamous cell CA

Cellular Localization: Membrane

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting
• Immunoprecipitation (Native only)
• Effect on EGF Binding (Inhibitory)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: Epidermal Growth Factor Receptor/EGFR Ab-10
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Mouse
• Quantity: 1 mL
• Research Discipline: EGFR Family
• Target Species: Human
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: 111.6
• Formulation: Ready-to-use for IHC (UVLP)
• Immunogen: Extracellular domain of human recombinant EGFR protein
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Prediluted