Epredia™ Lab Vision™ GRP94 Rabbit Polyclonal Antibody with BSA and azide

Ensure accurate, reproducible results in immunohistochemistry experiments with Epredia™ GRP94, Rabbit Polyclonal Antibody.

Supplier:  Epredia™ RB10642R7

Catalog No. RB10642R7

Description

Heat shock protein (HSP) molecular chaperones are environmental stress inducible gene products. The human HSP 90 family consists of 17 genes classified into four classes: HSP90AA, HSP90AB, HSP90B and TRAP. HSP 90 family members guide the normal folding, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. GRP 94, glucose regulated protein 94 kDa, a HSP90 family member, (also known as tumor rejection antigen 1 (TRA1), ECGP and GP96), localizes to the ER, is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1. TRAP1 (TNF receptor-associated protein 1), also designated HSP 75 is a mitochondrial matrix component that plays a role in the induction of apoptosis in response to reactive oxygen species.

Host Species: Rabbit

Species Reactivity: Human. Others not known.

Epitope: C-terminal

Immunogen: Synthetic peptide corresponding to C-terminal of human GRP94

Molecular Weight: 94 kDa

Positive Control: Breast CA

Cellular Localization: Cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: GRP94
• Classification: Polyclonal
• Host Species: Rabbit
• Purification Method: Breast CA
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Prediluted

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Immunogen: Synthetic peptide corresponding to C-terminal of human GRP94
• Quantity: 7 mL
• Research Discipline: Cancer and Tumor Biology
• Target Species: Human