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HER-2/c-erbB-2/neu Ab-1 Rabbit Polyclonal Antibody, Epredia™

Recommended for Immunohistochemistry (Formalin/paraffin), Western Blotting and Immunoprecipitation, Epredia™ HER-2/c-erbB-2/neu Ab-1, Rabbit Polyclonal Antibody provides accurate, reproducible results.

Manufacturer:  Epredia RB103P1ABX

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Catalog No. RB103P1ABX

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Monkey, Rat and Mouse. Others not tested.

Epitope: C-terminal

Immunogen: Synthetic peptide derived from C-terminus of human HER-2/c-erbB-2 protein. This sequence is identical in rat neu protein.

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or T47D cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

HER-2/c-erbB-2/neu Ab-1
Polyclonal
Unconjugated
Synthetic peptide derived from C-terminus of human c-erbB-2/HER-2 protein. This Sequence is identical in rat neu protein.
RUO
Primary
Concentrated
Immunoprecipitation, Western Blot
1mg/mL
Rabbit
500 μL
Oncogenesis
Human, Mouse, Non-human Primate
IgG
SDS
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