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HER-2/c-erbB-2/neu Ab-4 Mouse Monoclonal Antibody, Epredia™
Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.
Supplier: Epredia MS301B1
Description
c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the proteinHost Species: Mouse
Clone: N12
Isotype: IgG1
Species Reactivity: Human. Does not react with mouse and rat. Others not tested.
Epitope: Extracellular domain
Immunogen: Intact SKBR-3 breast cancer cells
Molecular Weight: 185 kDa
Positive Control: SKBR-3 cells, or Breast CA
Cellular Localization: Membrane
Recommended for:
- Immunofluorescence
- Immunoprecipitation (Not suitable)
- Inhibits Tumor Growth (∽90%)
- Inhibits Cell Proliferation
- Effect on HER-2 Internalization (Moderate)
- Electron Microscopy
Note:
USA: RUO; Int'l: RUO
Specifications
HER-2/c-erbB-2/neu Ab-4 | |
Monoclonal | |
200μg/mL | |
Mouse | |
500 μL | |
EGFR Family | |
Human | |
IgG1 |
Immunofluorescence, Immunohistochemistry (Frozen) | |
N12 | |
Biotin | |
Intact SKBR-3 breast cancer cells | |
RUO | |
Primary | |
Concentrated |
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