HER-2/c-erbB-2/neu Ab-4 Mouse Monoclonal Antibody, Epredia™

Provide accurate, reproducible results with the Epredia™ HER-2/c-erbB-2/neu Ab-4, Mouse Monoclonal Antibody.

Supplier:  Epredia MS301P1ABX

Catalog No. MS301P1ABX

Description

c-erbB-2, second member (c-erbB-2/HER-2/neu) of the c-erbB family is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein

Host Species: Mouse

Clone: N12

Isotype: IgG1

Species Reactivity: Human. Does not react with mouse and rat. Others not tested.

Epitope: Extracellular domain

Immunogen: Intact SKBR-3 breast cancer cells

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

• Immunofluorescence
• Immunoprecipitation (Not suitable)
• Inhibits Tumor Growth (∽90%)
• Inhibits Cell Proliferation
• Effect on HER-2 Internalization (Moderate)
• Electron Microscopy

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: HER-2/c-erbB-2/neu Ab-4
• Classification: Monoclonal
• Concentration: 1mg/mL
• Host Species: Mouse
• Quantity: 100 μL
• Research Discipline: EGFR Family
• Target Species: Human
• Isotype: IgG1

• Applications: Immunofluorescence, Immunohistochemistry (Frozen)
• Clone: N12
• Conjugate: Unconjugated
• Immunogen: Intact SKBR-3 breast cancer cells
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Concentrated