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HER-2/c-erbB-2/neu Ab-8 Mouse Monoclonal Antibody, Epredia™

Recommended for Immunohistochemistry, Western Blotting and Immunoprecipitation (Native and Denatured), Epredia™ HER-2/c-erbB-2/neu Ab-8, Mouse Monoclonal Antibody provides accurate, reproducible results.

Manufacturer:  Epredia MS325P0

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Catalog No. MS325P0


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Description

Description

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein. The c-erbB-2 protein is overexpressed in a variety of carcinomas especially those of breast and ovary.

Host Species: Mouse

Clone: e2-4001

Isotype: IgG1

Species Reactivity: Human, Mouse and Rat. Others not tested.

Epitope: Cytoplasmic domain

Immunogen: Cytoplasmic domain of recombinant human HER-2/c-erbB-2 oncoprotein

Molecular Weight: 185 kDa

Positive Control: SKBR-3 cells, or T47D cells, or Breast CA

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry
  • Western Blotting
  • Immunoprecipitation (Native and Denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

HER-2/c-erbB-2/neu Ab-8
Monoclonal
200μg/mL
Mouse
100 μL
Oncogenesis
Human, Mouse, Rat
IgG1
Immunoprecipitation
e2-4001
Unconjugated
Cytoplasmic domain of recombinant human c-erbB-2/HER-2 oncoprotein
RUO
Primary
Concentrated
SDS
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