HER-2/c-erbB-2/neu Ab-8 Mouse Monoclonal Antibody, Epredia™
Recommended for Immunohistochemistry, Western Blotting and Immunoprecipitation (Native and Denatured), Epredia™ HER-2/c-erbB-2/neu Ab-8, Mouse Monoclonal Antibody provides accurate, reproducible results.
Manufacturer: Epredia MS325P0
Descriptionc-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of primary breast and ovarian tumors were found to overexpress the protein. The c-erbB-2 protein is overexpressed in a variety of carcinomas especially those of breast and ovary.
Host Species: Mouse
Species Reactivity: Human, Mouse and Rat. Others not tested.
Epitope: Cytoplasmic domain
Immunogen: Cytoplasmic domain of recombinant human HER-2/c-erbB-2 oncoprotein
Molecular Weight: 185 kDa
Positive Control: SKBR-3 cells, or T47D cells, or Breast CA
Cellular Localization: Membrane
- Western Blotting
- Immunoprecipitation (Native and Denatured)
USA: RUO; Int'l: RUO
|Human, Mouse, Rat|
|Cytoplasmic domain of recombinant human c-erbB-2/HER-2 oncoprotein|
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