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  6. MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, Epredia™

MGMT (O-methylguanine-DNA methyltransferase) Ab-1 Mouse Monoclonal Antibody, Epredia™

Catalog No. MS470P0 Shop All Epredia Products
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Quantity:
100 μL
200 μL
500 μL
1 mL
Conjugate:
Biotin
Unconjugated
Form:
Concentrated
Concentration:
1mg/mL
200μg/mL
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Product selection table with 8 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity Conjugate Form Concentration
MS470P0 100 μL Unconjugated Concentrated 200μg/mL
MS470B1 500 μL Biotin Concentrated 200μg/mL
MS470B 1 mL Biotin Concentrated 200μg/mL
MS470P1 500 μL Unconjugated Concentrated 200μg/mL
MS470P 1 mL Unconjugated Concentrated 200μg/mL
MS470B0 100 μL Biotin Concentrated 200μg/mL
MS470P1ABX 100 μL Unconjugated Concentrated 1mg/mL
MS470PABX 200 μL Unconjugated Concentrated 1mg/mL
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Catalog No. MS470P0 Supplier Epredia Supplier No. MS470P0

Description

Epredia™ MGMT (O-methylguanine-DNA methyltransferase) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

Cancer chemotherapeutic alkylating agents (e.g. BCNU,) act by inducing formation of lethal cross-links at the O-alkylguanine position in DNA. MGMT transfers alkyl adducts from the O-position of guanine in DNA (prior to cross-link formation) to a cysteine residue in its own sequence, thereby restoring DNA to its intact state. This transfer inactivates the MGMT enzyme and is irreversible; hence the level of MGMT in a cell is directly proportional to the level of DNA-damage it can tolerate. In normal tissues, MGMT acts as a suppressor of mutation and carcinogenesis. Tumors with high levels of MGMT are likely be drug-resistant.

Host Species: Mouse

Clone: MT 3.1

Isotype: IgG1

Species Reactivity: Human. Also reacts weakly with Mouse, Rat and Hamster. Others not known.

Epitope: aa 8-221

Immunogen: Purified recombinant human MGMT protein

Molecular Weight: 25kDa

Positive Control: Raji cells, Colon CA

Cellular Localization: Nuclear and cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen MGMT (O-methylguanine-DNA methyltransferase) Ab-1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone MT 3.1
Concentration 200μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Purified recombinant human MGMT protein
Quantity 100 μL
Regulatory Status RUO
Research Discipline Enzyme
Primary or Secondary Primary
Target Species Hamster, Human, Mouse, Rat
Form Concentrated
Isotype IgG1
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