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  6. Microphthalmia (Transcription Factor) (MiTF) Ab-2 Mouse Monoclonal Antibody, Epredia™

Microphthalmia (Transcription Factor) (MiTF) Ab-2 Mouse Monoclonal Antibody, Epredia™

Catalog No. MS772P1 Shop All Epredia Products
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Quantity:
100 μL
200 μL
500 μL
1 mL
Conjugate:
Unconjugated
Form:
Concentrated
Prediluted
Concentration:
1mg/mL
200μg/mL
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Catalog No. Quantity Conjugate Form Concentration
MS772P1 500 μL Unconjugated Concentrated 200μg/mL
MS772P1ABX 100 μL Unconjugated Concentrated 1mg/mL
MS772P 1 mL Unconjugated Concentrated 200μg/mL
MS772PABX 200 μL Unconjugated Concentrated 1mg/mL
MS772R1 1 mL Unconjugated Prediluted -
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Description

Ensure accurate, reproducible results in immunohistochemistry experiments with the Epredia™ Microphthalmia (Transcription Factor) (MiTF) Ab-2, Mouse Monoclonal Antibody.

Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.

Host Species: Mouse

Clone: D5

Isotype: IgG1/κ

Species Reactivity: Human and Dog. Does not react with mouse and rat. Others not known.

Epitope: N-terminal

Immunogen: N-terminal fragment of human Mi protein

Molecular Weight: 52-56kDa doublet

Positive Control: 501 Mel cells, Melanoma

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting (Not verified)
  • Gel Supershift

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen Microphthalmia (Transcription Factor) (MiTF) Ab-2
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone D5
Concentration 200μg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen N-terminal fragment of human Mi protein
Quantity 500 μL
Regulatory Status RUO
Research Discipline Transcription Regulation
Primary or Secondary Primary
Target Species Canine, Human
Form Concentrated
Isotype IgG2a κ
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