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  6. Epredia™ Lab Vision™ p53 Rabbit Monoclonal Antibody (Clone Y5)

Epredia™ Lab Vision™ p53 Rabbit Monoclonal Antibody (Clone Y5)

Catalog No. RM2103R1 Shop All Epredia Products
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Quantity:
100 μL
1 mL
7 mL
12 mL
Form:
Concentrated
Prediluted
Ready-to-Use
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Catalog No. Quantity Form
RM2103R1 1 mL Prediluted
RM2103S0 100 μL Concentrated
RM2103S 1 mL Concentrated
RM2103R7 7 mL Prediluted
RM2103RQ 12 mL Ready-to-Use
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Catalog No. RM2103R1 Supplier Epredia™ Supplier No. RM2103R1

Description

Employ part of a comprehensive antibody portfolio with the Epredia™ p53, Rabbit Monoclonal Antibody (Clone Y5).

p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein. p53 senses DNA damage and possibly facilitaes repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. p53 is detected by immunostains only if the mutation causes protein stability (although protein may be nonfunctional) or a physiologic response. The physiologic response may be due to genetic changes induced by cellular stress from anoxia or aneuploidy; or genetic damage to other pathways controlling p53 such as MDM2 or alternative reading frame.

Host Species: Rabbit

Clone: Y5

Species Reactivity: Human.Others not known.

Immunogen: A synthetic peptide derived from N- terminal residues of human p53

Molecular Weight: 53kDa

Positive Control: Colon or Breast CA

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)

Specifications

Antigen p53
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone Y5
Conjugate Unconjugated
Formulation Ready-to-use for IHC (UVLP)
Host Species Rabbit
Immunogen A synthetic peptide derived from N- terminal residues of human p53
Quantity 1 mL
Regulatory Status IVD
Research Discipline Cancer and Tumor Biology
Primary or Secondary Primary
Target Species Human
Form Prediluted
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