Epredia™ Lab Vision™ Raf-1 (Phospho-specific) Ab-2 Rat Monoclonal Antibody with BSA and azide

Provide accurate, reproducible results with the Epredia™ Raf-1 (Phospho-specific) Ab-2, Rat Monoclonal Antibody.

Supplier:  Epredia™ RT1732R1

Catalog No. RT1732R1

Description

Raf1 is an important mediator of signal transduction pathway. It is activated through activation by Src and protein kinase C. It further phosphorylates Mek1 and cdc25. It can bind to GTP-bound Ras through N-terminal domain. It also interacts with hsp90 and 14.3.3 family of proteins.

Host Species: Rat

Clone: pS338[DPR/2/2A/3A]

Isotype: IgG1

Species Reactivity: Human. Others not known.

Epitope: GQRDS™SYY™WEIEAS

Immunogen: A synthetic peptide corresponding to aa GQRDS™SYY™WEIEAS

Molecular Weight: 74kDa

Positive Control: Tonsil

Cellular Localization: Nuclear Ab-2 binds to phosphorylated serine residue at aa338. It does not bind to unactivated Raf-1 or Raf-1 phosphorylated at Y341 and S339.

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO


General References:

1. Mason C S, et al. (1999) EMBO J, 18:2137-2148.

Specifications

• Antigen: Raf-1 (Phospho-specific) Ab-2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Host Species: Rat
• Quantity: 1 mL
• Research Discipline: Signal Transduction
• Target Species: Human
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin)
• Clone: pS338[DPR/2/2A/3A]
• Formulation: Ready-to-use for IHC (UVLP)
• Immunogen: A synthetic peptide corresponding to aa GQRDSasteriskSYYasteriskWEIEAS
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Form: Prediluted