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  6. Epredia™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Epredia™ Lab Vision™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, BSA and azide

Catalog No. MS1207PABX Shop All Epredia Products
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Quantity:
100 μL
200 μL
500 μL
1 mL
Concentration:
1mg/mL
200μg/mL
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Catalog No. Quantity Concentration
MS1207PABX 200 μL 1mg/mL
MS1207P0 100 μL 200μg/mL
MS1207P1 500 μL 200μg/mL
MS1207P 1 mL 200μg/mL
MS1207P1ABX 100 μL 1mg/mL
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Description

Epredia™ SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1, Mouse Monoclonal Antibody provides accurate, reproducible results.

SREBP-1 and -2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or -2, an ∽480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.

Host Species: Mouse

Clone: 2A4

Isotype: IgG1/κ

Species Reactivity: Human and Hamster. Others not known.

Epitope: aa 301-407

Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1

Molecular Weight: 125kDa (precursor) and 60-70kDa (cleaved)

Positive Control: HeLa and IMR5 cells

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

  • Western Blotting
  • Immunoprecipitation (Not verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1
Applications Immunoprecipitation, Western Blot
Classification Monoclonal
Clone 2A4
Concentration 1mg/mL
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1
Quantity 200 μL
Regulatory Status RUO
Research Discipline Transcription Regulation
Primary or Secondary Primary
Target Species Hamster, Human
Form Concentrated
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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