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Tocris Bioscience™ Lactacystin
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Catalog No. 2267200U
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Quantity:
200 μg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Cell-permeable, potent and selective proteasome inhibitor

A cell-permeable, potent and selective proteasome inhibitor. A Streptomyces metabolite that is thought to bind irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2a neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10 μM).

Chemical Identifiers

CAS 133343-34-7
Molecular Formula C15H24N2O7S

Specifications

Quantity 200 μg
Formula Weight 376.42
Purity >98%
Molecular Weight (g/mol) 376.424
Chemical Name or Material Lactacystin

Safety and Handling

Recommended Storage Desiccate at -20°C
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