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Invitrogen™ Lactoferrin Monoclonal Antibody (1A10)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA533350
Description
Product is supplied at 1 mL (100 μL/mL). Application Notes: Flow cytometry - For intracellular staining 293 cells were permeabilized and stained with 2 μg/mL Lactoferrin Monoclonal Antibody (1A10).
Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
Specifications
Lactoferrin | |
Monoclonal | |
100 μg/mL | |
PBS with 0.1% BSA and 0.02% sodium azide | |
P08071 | |
LTF | |
Mouse lactoferrin peptide. | |
100 μg | |
Primary | |
Mouse | |
Antibody | |
IgG2b |
ELISA, Flow Cytometry | |
1A10 | |
Unconjugated | |
LTF | |
Bovine Lactoferrin; CKRX; Csp82; epididymis luminal protein 110; GIG12; Growth-inhibiting protein 12; HEL110; HLF2; Kaliocin 1; Kaliocin1; kaliocin-1; lactoferricin; Lactoferricin H; Lactoferricin-B; Lactoferricin-H; Lactoferrin; lactoferroxin; LactoferroxinA; Lactoferroxin-A; LactoferroxinB; Lactoferroxin-B; LactoferroxinC; Lactoferroxin-C; Lactotransferrin; LF; Lfcin H; Lfcin-B; LfcinH; Lfcin-H; LTF; minisatellite 10r detected by probe MMS10; MMS10R; Ms10r; N lobe; neutrophil lactoferrin; talalactoferrin | |
Mouse | |
Protein G | |
RUO | |
17002 | |
4°C | |
Liquid |
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