Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Lactoferrin Mouse anti-Human, Clone: B97, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

$79.00 - $208.00

Specifications

Antigen lactoferrin
Clone B97
Target Species Human
Conjugate Unconjugated
Isotype IgG1
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-134-94 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14660480
25 μg Each for $79.00
Add to cart
 
50-134-95 Non-distribution product as customer accommodation.
View Documents
Invitrogen
14660482
100 μg Each for $208.00
Add to cart
 
Description

Description

Description: This B97 monoclonal antibody reacts with human lactoferrin. This 80-kDa glycoprotein is detectable in the kidney, lung, pancreas, gallbladder, prostate, seminal vesicle, gut, and liver. Lactoferrin is also present in mucosal secretions such as breast milk, tears, and saliva. In immune cells, high levels of lactoferrin can be found within the secondary granules of neutrophils, but not in lymphocytes or monocytes. A member of the transferrin family of proteins, lactoferrin binds two iron molecules to mediate its transport and storage. Lactoferrin plays an important role in host defense against pathogens and can regulate adaptive immune responses. Receptors for lactoferrin are present on the surface of lymphocytes, granulocytes, monocytes, mast cells, epithelial, and endothelial cells. Applications Reported: This B97 antibody has been reported for use in immunoblotting (WB) and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This B97 antibody has been tested using high pH antigen retrieval immunohistochemistry on formalin-fixed paraffin embedded human infiltrating ductal carcinoma and by western blot on reduced human saliva lysate. For immunohistochemistry, this antibody can be used at less than or equal to 10 µg/mL. For western blotting, the B97 antibody can be used at less than or equal to 1 µg/mL.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered. Lactoferrin (LF) is an iron binding glycoprotein. LF consists of a single polypeptide chain (approximately 80 kDa) folded into two structurally homologous lobes, each of which can reversibly bind one ferric ion (Fe3+). LF is found in external fluids, including milk and mucosal secretions, and is a prominent component of secondary granuals of neutrophils. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
Specifications

Specifications

lactoferrin
Human
IgG1
Monoclonal
Liquid
Antibody
4° C
B97
Unconjugated
Immunohistochemistry (Paraffin), Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO

For Research Use Only.

Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit