LAG3 Monoclonal Antibody (OTI5C3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA807073

Catalog No. 50-168-1387

Description

CD-223 (LAG-3, Lymphocyte-activation protein 3) is a 70 kDa surface glycoprotein belonging to the Ig superfamily. CD-223 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of CD-223 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express CD-223 at significantly higher levels than CD4+ T cells. Coexpression of CD-223 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells). LAG-3 contains 4 extracellular Ig-like domains and its gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate homology of CD-223 to CD4.

Specifications

• Antigen: LAG3
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: LAG3
• Gene Alias: CD223
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3902
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Clone: OTI5C3
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P18627
• Gene Symbols: LAG3
• Immunogen: Human recombit protein fragment corresponding to amino acids 66-332 of human LAG3 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b