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LAIR-1 (CD305) Mouse, anti-Human, R718, Clone: DX26, BD OptiBuild™
Mouse Monoclonal Antibody
Supplier: BD Biosciences 752267
Description
The DX26 monoclonal antibody specifically binds to Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1/ hLAIR1/Leukocyte-associated Ig-like receptor 1) that is encoded by LAIR1, and also known as, CD305. LAIR-1 is a ∼32 kDa type I transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory (ITIM) motifs. LAIR-1 is expressed on T cells, B cells, NK cells, monocytes, and dendritic cells. LAIR-1 recruits SHP-1 and SHP-2 tyrosine phosphatases upon activation. Crosslinking of the LAIR-1 expressed on T cells or NK cells can result in strong inhibition of cell-mediated cytotoxicity. Although it is structurally related to human killer cell inhibitory receptors, LAIR-1 does not appear to recognize MHC class I molecules and thus represents a novel MHC class I-independent mechanism of NK cell regulation.
Specifications
| LAIR-1 (CD305) | |
| Monoclonal | |
| R718 | |
| 50 μg | |
| Primary | |
| Refrigerate Upon Arrival |
| Flow Cytometry | |
| DX26 | |
| Mouse | |
| RUO | |
| Human | |
| Liquid |
Safety and Handling
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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