LAIR1 Mouse anti-Human, Clone: 9.1C3, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP2478000.2MG

Catalog No. NBP247800B

Description

LAIR1 Monoclonal antibody specifically detects Antigen in Human samples. It is validated for Flow Cytometry, Immunofluorescence.

Specifications

• Antigen: LAIR1
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Dilution: Flow Cytometry : 0.5 - 1 ug/million cells in 0.1 ml, Immunofluorescence : 0.5 - 1.0 ug/ml, CyTOF-ready
• Gene Alias: CD305 antigen, CD305leukocyte-associated Ig-like receptor 1, hLAIR1, LAIR-1, leukocyte-associated immunoglobulin-like receptor 1
• Host Species: Mouse
• Molecular Weight of Antigen: 40 kDa
• Quantity: 0.2 mg
• Primary or Secondary: Primary
• Test Specificity: Recognizes a single protein of 40kDa, identified as the CD305 (LAIR1). It is an inhibitory receptor, expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. This MAb is expressed on CD34 positive hematopoietic progenitors. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. This MAb is identical to LAIR-1, based on the fact that it not only precipitated a protein of 40kDa but it also binds specifically to LAIR-1 cDNA transfected COS7 cells as well as recognizes LAIR-1 fusion protein in ELISA. LAIR-1 expresses on hematopoietic progenitor, implicating its role in the regulation of hematopoiesis at early stage.
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Isotype: IgG2 κ

• Applications: Flow Cytometry, Immunofluorescence, CyTOF
• Clone: 9.1C3
• Conjugate: Unconjugated
• Formulation: PBS with No Preservative
• Gene Symbols: LAIR1
• Immunogen: Human Lymphocytes and Large Granular Lymphocytes (LGL)
• Purification Method: Protein A or G purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3903
• Target Species: Human
• Form: Purified