Invitrogen™ LAIR1 Polyclonal Antibody

Catalog No.	Quantity
PIPA587648	100 μL

Catalog No. PIPA587648 Supplier Invitrogen™ Supplier No. PA587648

Description

Rabbit Polyclonal Antibody

Positive Samples: B-cell, Jurkat, HL-60, Raji, Mouse brain, Mouse liver, Mouse lung, Rat liver; Cellular Location: Cell membrane, Single-pass type I membrane protein Immunogen sequence: QEEDLPRPSI SAEPGTVIPL GSHVTFVCRG PVGVQTFRLE RDSRSTYNDT EDVSQASPSE SEARFRIDSV REGNAGLYRC IYYKPPKWSE QSDYLELLVK ESSGGPDSPD TEPGSSAGPT QRPSDNSHNE HAPASQGLKA EH.

CD305, also known as LAIR1, is a type I transmembrane glycoprotein with an extracellular Ig-like domain and two intracellular ITIMs. It is expressed on a wide range of immune cells, including T, NK, and B cells, monocytes, dendritic cells, eosinophils, basophils, and mast cells. In humans, CD305 is also present on CD34+ hematopoietic progenitor cells and thymocytes. Several isoforms exist due to alternative splicing, with expression varying between cell types. CD305 functions as an inhibitory receptor, playing a key role in regulating immune responses. It blocks cytokine-mediated signaling, cell proliferation, and apoptosis. In NK, B, and T cells, CD305 modulates cytolytic functions and cytokine production, down-regulating IL2 and IFNG in CD4+ T cells while inducing transforming growth factor beta. In B cells, it reduces IgG and IgE production and decreases IL8, IL10, and TNF secretion. Activation of CD305 through tyrosine phosphorylation recruits phosphatases PTPN6 and PTPN11, although it may also function independently of SH2-containing phosphatases. It inhibits differentiation of peripheral blood precursors into dendritic cells and has been shown to induce apoptosis in myeloid leukemia cell lines. Collagens are identified as ligands for CD305, underscoring its role in immune regulation.

Specifications

• Antigen: LAIR1
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.11 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: LAIR1
• Gene Accession No.: Q6GTX8
• Gene Alias: 5133400O11Rik; BB115266; CD305; D7Bwg0421e; immunoglobulin heavy chain variable region; Lair1; Lair-1; leukocyte associated immunoglobulin like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated Ig-like receptor-1; leukocyte-associated immunoglobulin-like receptor 1; rLAIR1
• Gene Symbols: LAIR1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-163 of human LAIR1 (NP_0022782).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 3903
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG