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Invitrogen™ Lamin A (Cleaved Asp230) Monoclonal Antibody (C.69.9)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515211

Catalog No. PIMA515211


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Description

Description

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with full length lamin A or C.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Lamin A (Cleaved Asp230)
Monoclonal
1 μg/mL
0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
P02545, P48678, P48679
LMNA
Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG1
Western Blot, Immunocytochemistry
C.69.9
Unconjugated
LMNA
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; Lmn1; LMNA; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32
Mouse
Affinity chromatography
RUO
16905, 4000, 60374
-20°C
Liquid
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