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Invitrogen™ Lamin A (Cleaved Asp230) Monoclonal Antibody (C.69.9)
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Catalog No. PIMA515211
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100 μL
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PIMA515211 100 μL
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Catalog No. PIMA515211 Supplier Invitrogen™ Supplier No. MA515211
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Description

Mouse Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with full length lamin A or C.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lamin A (Cleaved Asp230)
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone C.69.9
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100 μg/mL BSA, 50% glycerol, 0.15M NaCl and <0.02% sodium azide; pH 7.5
Gene LMNA
Gene Accession No. P02545, P48678, P48679
Gene Alias 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; Lmn1; LMNA; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32
Gene Symbols LMNA
Host Species Mouse
Immunogen Synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16905, 4000, 60374
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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