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Lamin A, mature Monoclonal Antibody (4A4), Active Motif™
SDP

Catalog No. 501993003
Encompass
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50-199-3003 100 μg
50-199-3004 10 μg
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Catalog No. 50-199-3003 Supplier Active Motif Supplier No. 39961
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Description

Mouse Monoclonal Antibody

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Specifications

Antigen Lamin A, mature
Applications Western Blot
Classification Monoclonal
Clone 4A4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene LMNA
Gene Accession No. P02545
Gene Alias 70 kDa lamin; BOS_2775; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; Lamin-A/C; LDP1; LFP; LGMD1B; Lmn1; LMNA; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32
Gene Symbols LMNA
Host Species Mouse
Immunogen This Lamin A, mature antibody was raised against a peptide within the C-terminus of mature human Lamin A.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4000
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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