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Invitrogen™ Lamin A Monoclonal Antibody (133A2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA106101

Catalog No. MA106101


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Description

Description

MA1-06101 detects lamin A in human, mouse, rat, bovine and canine samples. MA1-06101 has sucessfully been used in immunocytochemistry, immunohistochemistry (paraffin), flow cytometry, and Western blotting procedures. The MA1-06101 immunogen is partially purified recombinant human lamin A.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Lamin A
Monoclonal
1 mg/mL
PBS with 0.09% sodium azide
P02545, P48678, P48679
LMNA
Partially purified recombinant human lamin A.
100 μg
Primary
Human, Mouse, Rat, Canine, Bovine
Antibody
IgG3
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
133A2
Unconjugated
LMNA
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product
Mouse
Ion-exchange Chromatography
RUO
16905, 4000, 404144, 480124, 60374
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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