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Invitrogen™ Lamin A Monoclonal Antibody (133A2)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA106101
Description
MA1-06101 detects lamin A in human, mouse, rat, bovine and canine samples. MA1-06101 has sucessfully been used in immunocytochemistry, immunohistochemistry (paraffin), flow cytometry, and Western blotting procedures. The MA1-06101 immunogen is partially purified recombinant human lamin A.
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Specifications
Lamin A | |
Monoclonal | |
1 mg/mL | |
PBS with 0.09% sodium azide | |
P02545, P48678, P48679 | |
LMNA | |
Partially purified recombinant human lamin A. | |
100 μg | |
Primary | |
Human, Mouse, Rat, Canine, Bovine | |
Antibody | |
IgG3 |
Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
133A2 | |
Unconjugated | |
LMNA | |
70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product | |
Mouse | |
Ion-exchange Chromatography | |
RUO | |
16905, 4000, 404144, 480124, 60374 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
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