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Invitrogen™ Lamin A Monoclonal Antibody (133A2)
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Catalog No. MA106101
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100 μg
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MA106101 100 μg
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Catalog No. MA106101 Supplier Invitrogen™ Supplier No. MA106101
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Description

Mouse Monoclonal Antibody

MA1-06101 detects lamin A in human, mouse, rat, bovine and canine samples. MA1-06101 has sucessfully been used in immunocytochemistry, immunohistochemistry (paraffin), flow cytometry, and Western blotting procedures. The MA1-06101 immunogen is partially purified recombinant human lamin A.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lamin A
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 133A2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene LMNA
Gene Accession No. P02545, P48678, P48679
Gene Alias 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; Dhe; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A; lamin A/C; lamin A/C-like 1; lamin C; lamin C2; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; Lmna; LMNA protein; LMNC; LMNL1; OTTHUMP00000015843; OTTHUMP00000015846; OTTHUMP00000015847; Prelamin-A/C; PRO1; renal carcinoma antigen NY-REN-32; unnamed protein product
Gene Symbols LMNA
Host Species Mouse
Immunogen Partially purified recombinant human lamin A.
Purification Method Ion-exchange chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16905, 4000, 404144, 480124, 60374
Target Species Bovine, Canine, Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG3
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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