Lamin-A Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A303432AT

Catalog No. 50-156-5121

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For ICC, formaldehyde fixation is recommended. Permeabilization with Triton-X 100 is recommended for formaldehyde-fixed cells. For IHC, epitope retrieval with c

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

Specifications

• Antigen: Lamin-A
• Classification: Polyclonal
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: P02545, P48678
• Gene Symbols: LMNA
• Immunogen: Between 400 and 450
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Conjugate: Unconjugated
• Gene: LMNA
• Gene Alias: 70 kDa lamin, cardiomyopathy, dilated 1A (autosomal domit), CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, lamin A/C-like 1, LDP1, LFP, LGMD1B, limb girdle muscular dystrophy 1B (autosomal domit), LMN1, LMNC, LMNL1, prelamin-A/C, PRO1, progeria 1 (Hutchinson-Gilford type), renal carcinoma antigen NY-REN-32
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16905, 4000
• Content And Storage: 4° C
• Form: Liquid