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Invitrogen™ Lamin B2 Monoclonal Antibody (GT144)
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Catalog No. PIMA517274
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100 μL
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Catalog No. Quantity
PIMA517274 100 μL
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Catalog No. PIMA517274 Supplier Invitrogen™ Supplier No. MA517274
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Description

Mouse Monoclonal Antibody

Recommended positive controls: U87-MG, SK-N-SH, IMR32, SK-N-AS, HepG2, HepG2 nuclear. Predicted reactivity: Bovine (83%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lamin B2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone GT144
Concentration 0.81 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene LMNB2
Gene Accession No. Q03252
Gene Alias EPM9; fc15d06; im:7142331; LAMB2; lamin; lamin A/C; lamin B2; lamin B2 S homeolog; lamin B3; lamin-B2; Lamin-L(II); LMN2; LMNA; lmnb2; lmnb2.S; lmnb2-a; lmnb2-b; MGC2721; RGD1563803; unnamed protein product; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
Gene Symbols LMNB2
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human Lamin B2. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84823
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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