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Invitrogen™ Lamin B2 Polyclonal Antibody
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Catalog No. PIPA5115516
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PIPA5115516 100 μL
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Catalog No. PIPA5115516 Supplier Invitrogen™ Supplier No. PA5115516
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total LMNB2.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Lamin B2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene LMNB2
Gene Accession No. P21619, Q03252
Gene Alias EPM9; fc15d06; im:7142331; LAMB2; lamin; lamin A/C; lamin B2; lamin B2 S homeolog; lamin B3; lamin-B2; Lamin-L(II); LMN2; LMNA; lmnb2; lmnb2.S; lmnb2-a; lmnb2-b; MGC2721; RGD1563803; unnamed protein product; wu:fb94e05; wu:fb95e12; wu:fc15d06; wu:fc49h03; XELAEV_18009631mg
Gene Symbols LMNB2
Host Species Rabbit
Immunogen A synthesized peptide derived from human LMNB2(Accession Q03252), corresponding to amino acid residues K200-Q250.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16907, 299625, 84823
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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