Invitrogen™ Laminin-221 Recombinant Rabbit Monoclonal Antibody (17H4L1)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 702272

Catalog No. PI702272

Description

This antibody is predicted to react with Monkey, Sheep, Cat and Bovine Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Laminin is a non-collagenous protein of basement membranes. By rotary shadowing it has a cross-like shape, consisting of one long arm, (400 kD) and three short arms (200 kD). Antibodies to laminin localize exclusively in basement membranes. Laminin is found throughout the basement membrane, but the reaction with the antibodies to laminin is more intense in the lamina lucida, the part of the basement membrane adjacent to the cell membrane. Laminin binds to type IV collagen, a component exclusively localized in the basement membrane. Laminin has been shown to play a role in cell adhesion and attachment in vivo and in vitro.

Specifications

• Antigen: Laminin-221
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.2
• Gene Accession No.: Q16363
• Gene Symbols: LAMA4
• Immunogen: Protein corresponding to Human LAMA4 (aa 1300-1500).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunocytochemistry
• Clone: 17H4L1
• Conjugate: Unconjugated
• Gene: LAMA4
• Gene Alias: CMD1JJ; LAMA3; LAMA4; LAMA4*-1; laminin [a]4; laminin alpha 4 chain; laminin subunit alpha 4; laminin subunit alpha-4; laminin, alpha 4; laminin-14 subunit alpha; Laminin-8 subunit alpha; laminin-9 subunit alpha; RGD1560062
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3910
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

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