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Invitrogen™ Laminin gamma-1 Polyclonal Antibody
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Catalog No. PIPA5101334
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PIPA5101334 100 μL
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Catalog No. PIPA5101334 Supplier Invitrogen™ Supplier No. PA5101334
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total LAMC1.

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Laminin gamma-1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene LAMC1
Gene Accession No. P02468, P11047
Gene Alias AA408497; B2e; basement membrane protein; LAMA; LAMA1; Lama-1; LAMB2; LAMC1; Laminin A chain; laminin B2 chain; laminin gamma 1 chain; laminin S; laminin subunit alpha 1; laminin subunit alpha-1; laminin subunit gamma 1; laminin subunit gamma-1; laminin, alpha 1; laminin, beta 2; laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1; laminin-1 subunit alpha; Laminin-1 subunit gamma; laminin-10 subunit gamma; Laminin-11 subunit gamma; laminin-2 subunit gamma; Laminin-3 subunit alpha; laminin-3 subunit gamma; Laminin-4 subunit gamma; laminin-6 subunit gamma; Laminin-7 subunit gamma; laminin-8 subunit gamma; Laminin-9 subunit gamma; PTBHS; S-LAM alpha; S-LAM gamma; S-LAM-alpha; S-laminin subunit alpha; S-laminin subunit gamma
Gene Symbols LAMC1
Host Species Rabbit
Immunogen A synthesized peptide derived from human LAMC1(Accession P11047), corresponding to amino acid residues A161-D211.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117036, 226519, 3915
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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