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Invitrogen™ Laminin beta-2 Polyclonal Antibody
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Catalog No. PIPA581986
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100 μL
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PIPA581986 100 μL
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Catalog No. PIPA581986 Supplier Invitrogen™ Supplier No. PA581986
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DLTDVQDENF NANHALSGLE RDRLALNLTL RQLDQHLDLL KHSNFLGAYD SIRHAHSQSA EAERRANTSA LAVPSPVSNS ASARHRTEAL MDAQKEDFNS KHMANQRALG KLSAHTHTLS LTDINELVCG APG Highest antigen sequence indentity to the following orthologs: Mouse - 83%, Rat - 82%.

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Laminin beta-2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene LAMB2
Gene Accession No. P55268
Gene Alias AW211941; Lamb2; Lamb-2; Laminin B1s chain; laminin chain B3; laminin chain beta 2; Laminin S; laminin subunit beta 2; laminin subunit beta-2; laminin, beta 2; laminin, beta 2 (laminin S); laminin-11 subunit beta; Laminin-14 subunit beta; laminin-15 subunit beta; Laminin-3 subunit beta; laminin-4 subunit beta; Laminin-7 subunit beta; laminin-9 subunit beta; LAMS; NPHS5; npht; SLAM; S-LAM beta; S-laminin subunit beta
Gene Symbols LAMB2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human LAMB2. Recombinant protein control fragment (Product #RP-101042).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3913
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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