Invitrogen™ Laminin gamma-1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590889

Catalog No. PIPA590889

Description

Positive Samples: LO2, Mouse heart, Mouse kidney, Rat heart Immunogen sequence: ECPACYRLVK DKVADHRVKL QELESLIANL GTGDEMVTDQ AFEDRLKEAE REVMDLLREA QDVKDVDQNL MDRLQRVNNT LSSQISRLQN IRNTIEETGN LAEQARAHVE NTERLIEIAS RELEKAKVAA ANVSVTQPES TGDPNNMTLL AEEARKLAER HKQEADDIVR VAKTANDTST EAYNLLLRTL AGENQTAFEI EELNRKYEQA KNISQDLEKQ AARVHEEAKR AGDKAVEIYA SVAQLS.

Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen and several proteoglycans. Basement membranes are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression and tissue architecture. Each Laminin is a heterotrimer of alpha, beta and gamma chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules and have unique and shared cell interactions mediated by Integrins, dystroglycan and cognate Laminin receptors. The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.

Specifications

• Antigen: Laminin gamma-1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: LAMC1
• Gene Alias: AA408497; B2e; basement membrane protein; LAMA; LAMA1; Lama-1; LAMB2; LAMC1; Laminin A chain; laminin B2 chain; laminin gamma 1 chain; laminin S; laminin subunit alpha 1; laminin subunit alpha-1; laminin subunit gamma 1; laminin subunit gamma-1; laminin, alpha 1; laminin, beta 2; laminin, gamma 1; laminin, gamma 1 (formerly LAMB2); laminin-1; laminin-1 subunit alpha; Laminin-1 subunit gamma; laminin-10 subunit gamma; Laminin-11 subunit gamma; laminin-2 subunit gamma; Laminin-3 subunit alpha; laminin-3 subunit gamma; Laminin-4 subunit gamma; laminin-6 subunit gamma; Laminin-7 subunit gamma; laminin-8 subunit gamma; Laminin-9 subunit gamma; PTBHS; S-LAM alpha; S-LAM gamma; S-LAM-alpha; S-laminin subunit alpha; S-laminin subunit gamma
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 117036, 226519, 3915
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Western Blot
• Concentration: 2.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P02468, P11047
• Gene Symbols: LAMC1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1275 of human LAMC1 (NP_0022843).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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